We help develop, evaluate, and optimize (bio)chemical processes

“Novasep was involved in the development of Proxima as a Joint Application Development partner. The software provides a unique environment to assess all stages of the industrialization of a process: from R&D development to the analysis of routine production. It fosters scale-up by easily converting lab recipes into flow or equipment diagrams and quickly evaluating various processes or scenarios. The interface is pleasant and user-friendly, I particularly appreciate the Basic Design and the databases. Besides, a special word for the Ypso Facto Team of engineers and developers who is very responsive in providing suitable and relevant solutions."

Magali ARNAUD, Industrialization Engineer, Novasep Pharma Solutions

“We are using the DSP software tool Ypso-Ionic® in the Calipso project at Sanofi. This tool is very user-oriented and facilitates visualization and analysis. For example, this tool makes it easy to calculate the distribution of eluates… when preparing a buffer, it makes it possible to calculate the pH in advance and check for errors. Use has been underway for a short time, but we estimate that the tool saves technician/executive time by around 10% over a week and standardizes the visualization of activities between people.”

Eric Calvosa - Project Coordinator Calipso - Global bioprocess expert – Sanofi

“During our cooperation with Ypso-Facto, by associating our respective expertises, predictive simulation and experiments, we managed reducing by 57% the solvent use for resin washing during SPPS.”

Olivier LUDEMANN-HOMBOURGER, Director Global – Innovation & Technology, PolyPeptide Laboratories

“GSK Engaged Ypso-Facto’s expertise, their Ypso-Ionic software and GPX approach to develop a mechanistic model of a complex ion-exchange purification process. Compared with the classical statistical DoE approach, only 25% of the experimental work was required, but we also achieved much more, including deep process understanding, troubleshooting, identification of trends and associated design space as well as multicolumn chromatography predesign. In addition to the technical project work, Ypso-Facto’s highly collaborative ways of working have increased our organizational expertise and allowed us to demonstrate the value of mechanistic modelling.”

Chris MCKAY, Principal Process Engineer, GSK

About the optimization of a multi-column Ion Exchange system :
<< In combination with AKBM “user-knowledge” and intuition, Ypso-Facto used experimental laboratory- and production-data and made simulation-models with the software “Ypso-Ionic”. With this GPX approach, Ypso-Facto identified the root cause of AKBM’s problem, supported AKBM in resolving these and as a consequence doubled our productivity and enhanced product purity. >>

Marion MASCHERIN, Chemical Engineer, Aker BioMarine

About the improvement of a complex production plant :
<< AKBM has also has had a successful collaboration with Ypso-Facto related to the software “Proxima”. AKBM has used “Proxima” along with Ypso-Facto experts’ support to exploit AKBM experimental data in a structured and collaborative way. AKBM were able to analyze the performance of a complex production-plant including 12 unit-operations. This work allowed AKBM to identify bottlenecks and do an economic evaluation (Opex) of our process. >>

Svein Ivar HOLM, Senior Lead Design Engineer, Aker BioMarine

“Novasep was involved in the development of Proxima as a Joint Application Development partner. The software provides a unique environment to assess all stages of the industrialization of a process: from R&D development to the analysis of routine production. It fosters scale-up by easily converting lab recipes into flow or equipment diagrams and quickly evaluating various processes or scenarios. The interface is pleasant and user-friendly, I particularly appreciate the Basic Design and the databases. Besides, a special word for the Ypso Facto Team of engineers and developers who is very responsive in providing suitable and relevant solutions.”

Magali ARNAUD, Industrialization Engineer, Novasep Pharma Solutions

“Our JM separation technologies R&D team at Sonning has had a long standing and highly valued relationship with Ypso-Facto®. Ypso-Facto® have developed a unique modelling/simulation environment, via its Ypso-Ionic® (formally ChromWorks™), software package that has proved its value to us both in successful separation process development and in application to business-critical problems. The world-renowned expertise of its founder, Roger Marc Nicoud, gives us a unique insight.

In addition, the wider Ypso team has a deep level of understanding of the fundamental science and engineering as well as a commercial awareness that gives them great customer focus. They have been willing to go beyond to help us build custom modelling tools that enable us to meet our corporate R&D needs and to deliver commercial value to the JM businesses involved with large scale separation processes. I have come to see Ypso as partner and not just a modelling software provider.”

Dr Paul O’Shaughnessy - Senior Principal Scientist – Johnson Matthey Technology Centre - Johnson Matthey