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Comparing multi-column chromatographic processes for purifying monosaccharides
Part I: A simplifed approach
Laurent David, Jay Yun, Roger-Marc Nicoud*
ABSTRACT This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are...
Innovative organic chemistry: a differentiating driver for CMOs
A methodological approach to develop technical competitive advantages
Marc-Olivier Simon,* Roger-Marc Nicoud
ABSTRACT: The fine chemicals segment is a field of continuous innovation with regards to new molecular structures in which Contract Manufacturing Organizations (CMOs) play a major role, in particular for the commercial-scale production of organic molecules. To face constant international competition...
From batch to continuous processes: a good answer, but what is the question? Part II*
The purification unit operations, specific situations, the complete process perspective
Roger-Marc Nicoud
ABSTRACT: The switch from batch to continuous process is a major topical question in the fine chemical, pharmaceutical and biopharmaceutical industries. In spite of a genuine interest, as shown by the profusion of recent literature and symposia on the topic, batch remains the widely accepted standard...
From batch to continuous processes: a good answer, but what is the question? Part I*
General considerations and the reaction unit perspective
Roger-Marc Nicoud
ABSTRACT: The switch from batch to continuous process is a major topical question in the fine chemical, pharmaceutical and biopharmaceutical industries. In spite of a genuine interest, as shown by the profusion of recent literature and symposia on the topic, batch remains the widely accepted standard...
A continuum theory for multicomponent chromatography modeling
David Pfister, Massimo Morbidelli,* Roger-Marc Nicoud
ABSTRACT: A continuum theory is proposed for modeling multicomponent chromatographic systems under linear conditions. The model is based on the description of complex mixtures, possibly involving tens or hundreds of solutes, by a continuum. The present approach is shown to be very efficient when...
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